Selinex (Selinexor 20mg)

Description

selinex is the best product in bangladesh

its mmanufacture by everest pharmaceuticals limited .

its plays an important role in tumor suppession .

COMPOSITION
Selinex tablet: Each film coated tablet contains Selinexor
INN 20 mg.
PHARMACOLOGY
Mechanism of Action
In nonclinical studies, Selinexor reversibly inhibits nuclear
export of tumor suppressor proteins (TSPs), growth
regulators, and mRNAs of oncogenic proteins by blocking
exportin 1 (XPO1). XPO1 inhibition by Selinexor leads to
accumulation of TSPs in the nucleus, reductions in several
oncoproteins, such as c‐myc and cyclin D1, cell cycle
arrest, and apoptosis of cancer cells. Selinexor demonstrated pro‐apoptotic activity in vitro in multiple myeloma cell
lines and patient tumor samples, and in murine xenograft
models.