Tagrix is the 1st global generic of osimertinib. This drug is a third generation EGFR inhibitor. Osimertinib (Tagrix) is the 1st and only drug of its kind approved by USFDA for the treatment of epidermal growth factor receptor (EGFR) positive Non- Small Cell Lung Cancer (NSCLC) patient with T790M mutation.
Tagrix Pediatric Use
The safety and effectiveness of Osimertinib in pediatric patients have not been established.
Tagrix Geriatric Use
No overall differences in effectiveness were observed based on age. Exploratory analysis suggest a higher incidence of Grade 3 and 4 adverse reactions (32% versus 25%) and more frequent dose modifications for adverse reactions (23% versus 17%) in patients 65 years or older as compared to those younger than 65 years.
Tagrix Presentation & Packaging:
Tagrix 40 Tablet: Each film coated tablet contains Osimertinib Mesylate INN equivalent to Osimertinib 40 mg.
Tagrix 80 Tablet: Each film coated tablet contains Osimertinib Mesylate INN equivalent to Osimertinib 80 mg.
Osimertinib belongs to the group of medicines called antineoplastic (cancer medicines). It works by interfering with the growth of cancer cells, which are eventually destroyed. Read More
Osimert 80 mg is the Bangladeshi version of osimertinib. It is formulated with the original formula. Original tagrisso and Bangladesh made Osimert work the same. Read More
Store Osimertinib at room temperature between 20°C to 25°C. Safely throw away medicine that is out of date or that you no longer need. Keep Osimertinib and all medicines out of the reach of children. Read More
The most common (>20%) adverse reactions (all grades) observed in Osimertinib-treated patients were diarrhea (42%), rash (41%), dry skin (31%), and nail toxicity (25%). The most frequent adverse reactions that led to dose reductions or interruptions were: electrocardiogram QTc prolonged (2.2%) and neutropenia (1.9%). Serious adverse reactions reported in 2% or more patients were pneumonia and pulmonary embolus.
Osimertinib is an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) that binds to certain mutant forms of EGFR (T790M, L858R, and exon 19 deletions) that predominate in non-small cell lung cancer (NSCLC) tumours following treatment with first-line EGFR-TKIs. As a third-generation tyrosine kinase inhibitor, osimertinib is specific for the gate-keeper T790M mutation which increases ATP binding activity to EGFR and results in a poor prognosis for late-stage disease. Furthermore, osimertinib has been shown to spare wild-type EGFR during therapy, thereby reducing non-specific binding and limiting toxicity. Osicent Price
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